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I had read some articles and seen some photos, but never heard any real gun peopll discuss them. I also have seen a S&W 686 with a Medusa conversion by P&A. What does anyone knwo of this pistol that will shoot .380 through 357 +p? Is anyone doing the conversion on modern 686, 608, 66, GP100 etc? Did Gary Reeder by them out?

I think it would be a fun range gun, and a great survival tool.

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US Patent 8453366. Take a look. Now have a nice day..

The last I heard anything about it was several years ago, and it was that Colt was working on a Medusa-sounding revolver. But I don't know if they actually bought the Medusa, or "borrowed" the concept. I could be mistaken about all of that.
I'm thinking it was called the "Survivor", but could even more mistaken there.

Philip & Rodgers made the Medusa multi-caliber revolver. I had one. It was neat but it sounds cooler than it is. The cylinder had a spring type extractor where the extractor tip would engage the rim of the cartridge as it slid in to the chamber. This is what allowed it to shoot so many calibers. Rimmed cartridges like .38 Spec & .357 Mag worked as normal. It was slow to reload due to the springiness of the extractor. The list of all of the calibers it shot was more impressive on paper. Most of the cartridges were obsolete or cost so much no one would use them. Not to mention some were listed on the chart multiple times. I really only ever used it with 9mm, .38 Special, .357 Magnum & .356 TSW. It's accuracy was nothing special but it maintained 2.5" groups at 20 to 25 yards regardless of the caliber used.

I got the "polymer" finish on it which was basically one of the shake & bake type "paints." The gun was cool looking and basically a K-frame smith IIRC so it handled nice and the trigger was that of a typical S&W of the era. The final metal prep wasn't all that as there were some little imperfections here and there. Nothing to really complain about.

All in all I would call it a novelty gun but not one I would consider for serious work. Truth be told you could have a 686 cut to use moonclips and get almost the same utility in cartridge choices.

I sold mine about two years ago. I think I got $650 or so for it. I don't miss it other than it was a neat conversation piece. I had to send it in for warranty work to have the extractor star unit replaced and I talked to the owner. He sold all of his remaining parts to Gary Reeder IIRC. He is making them into a revolver he calls the "Scorpion" for about $1600.